Bettie Barnard was born in Rustenburg in 1914. She studied at University of Pretoria and furthered her studies at the Pretoria Art Centre.
Throughout her life as an artist, Bettie explored with various mediums and switched between non-figurative works and figurative art forms.
Her first one-man exhibition was in 1946 and from thereon in she exhibited in places such as Paris, London and Taiwan.
She was a painter and graphic artist of portraits, still life, genre, figures and abstracts, working in oil, watercolor, acrylic, mixed media, collaged canvas and in various graphic media.
Bettie Cilliers-Barnard is represented in the following collections: Hester Rupert Art Museum, Graaff-Reinet; King George VI Art Gallery, Port Elizabeth; National Museum , Bloemfontein; Potchefstroom Museum; Potchefstroom University for CHE; SA National Gallery, Cape Town; University of Natal; University of the Orange Free State; University of Pretoria; University of Pretoria; University of South Africa; University of Stellenbosch; University of the Witwatersrand; Willem Annandale Art Gallery, Lichtenburg; William Humphreys Art Gallery Kimberley.